Shoot it, snort it, drip it, suck it...the many routes of Ketamine administration!
The route of administration for Ketmaine is varied and diverse. Ketamine can be injected, infused via IV, snorted/inhaled, swallowed or sucked on. There is even evidence of rectal and intrathecal administration! This offers exciting opportunities for ease and safety of administration as well as a chance to modulate the experience by changing the route.
IV administration is 100% bioavailable. This means that 100% of the drug winds up in your system and is available for activity. The injection route is 93% bioavailable and the oral route is somewhere around 20% bioavailable. The onset of effect is therefore different for each route. The injection and IV routes are often colloquially regarded as the "rocket ship" experience since it rapidly transports users into another realm. The oral route has a much slower and gentle onset and can take 15-30 minutes to reach full effect. Many first-time users prefer to start with the oral dose for this reason.
Ketamine is metabolized by the liver and has a metabolite, norketamine that is about 1/4 as psychoactive. It is metabolized by enzymes from the cytochrome P450 pathway. In the section on risks, you will see that using other substances or drugs that use the same pathway can affect how quickly or how well one eliminates Ketamine.
5 Lessons
Curious about Ketamine: An overview
Ketamine is a synthetic drug discovered in the 1960s. Initially used as an anesthetic, Ketamine has become popular for a whole host of reasons.
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*Please take note: This module is for general educational purposes only. Jennifer Boyd is a Physician Associate licensed in the states of CT and NY. You are required to have your own licensed medical provider to help you manage your health.